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KMID : 1145120200180020137
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Asian Journal of Beauty and Cosmetology
2020 Volume.18 No. 2 p.137 ~ p.148
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Physiological Characteristics of Germinated Oat (Avena sativa) Extract as Raw Material for Cosmetics
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Hwang Ji-U
Yang Yung-Hun
Choe Tae-Boo
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Abstract
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Purpose: This study evaluated the antioxidant and anti-inflammatory ability of germinated and non-germinated oat (Avena sativa) grain for developing a new cosmetic raw material.
Methods: Some local oat grains were freeze-dried (cryodesiccated) and extracted using 95% ethanol to obtain a germinated oat, and the non-germinated oat extract was obtained by redrying. The oat grains were germinated at 20℃ for 5 days and extracted using the same procedure as described above. Subsequently, the extracts were applied to cultured cells to determine their antioxidant, anti-inflammatory, anti-melanogenic, and anti-aging effects.
Results: For the extract of germinated oat, 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity, and nitric oxide (NO) generation inhibition ability was increased to 112% and 43%, respectively, compared with the non-germinated. The RAW264.7 cells stimulated with lipopolysaccharides (LPS) revealed that treatment with the germinated oat extract could downregulate the expression of inflammatory factors, such as cyclooxygenase 2, interleukin 1beta, and interleukin 6 by 35%, 17.5%, and 22%, respectively. This enhanced anti-inflammatory effect could be as a result of increased avenanthramide during the germination period.
Conclusion: Germinated oat grain extract showed an enhanced ability of antioxidant and anti-inflammatory properties. For this reason, the extract of germinated oat grain can be a good source of raw material for cosmetic industry.
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KEYWORD
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Avena sativa extract, Germination, Avenanthramide, Anti-inflammatory, Cosmetic raw material
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